{"id":2711,"date":"2026-06-22T23:08:57","date_gmt":"2026-06-22T23:08:57","guid":{"rendered":"https:\/\/reliablemovingcrews.com\/?p=2711"},"modified":"2026-06-22T23:08:57","modified_gmt":"2026-06-22T23:08:57","slug":"definiums-lsd-based-depression-pill-delivers-strong-late-stage-results-shares-surge","status":"publish","type":"post","link":"https:\/\/reliablemovingcrews.com\/?p=2711","title":{"rendered":"Definium&#8217;s LSD-based depression pill delivers strong late-stage results, shares surge"},"content":{"rendered":"<div>\n<div>\n<div>\n<ul>\n<li>Companies<\/li>\n<\/ul>\n<\/div>\n<div>\n<ul>\n<li><svg><\/svg>\n<div>\n<div>\n<div><button><span><span>Follow<\/span><\/span><\/button><\/div>\n<\/div>\n<\/div>\n<\/li>\n<li><svg><\/svg>\n<div>\n<div>\n<div><button><span><span>Follow<\/span><\/span><\/button><\/div>\n<\/div>\n<\/div>\n<\/li>\n<li><svg><\/svg>\n<div>\n<div>\n<div><button><span><span>Follow<\/span><\/span><\/button><\/div>\n<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div>June 22 (Reuters) &#8211; Definium Therapeutics (DFTX.O)<svg><\/svg><span>, opens new tab<\/span> said a single dose of its LSD-based experimental pill \u200bsignificantly reduced symptoms of major depression in patients in a late-stage \u200ctrial, sending its shares soaring 55% to a more than four-year high on Monday.<\/div>\n<div>The experimental drug helped patients record significantly lower scores on a standard depression scale than those \u200bon placebo after six weeks, with an 8.1-point difference, meeting the \u200btrial&#8217;s main goal, the company said.<\/div>\n<div>The pill, DT120, belongs to a \u2060class of drugs known as classic psychedelics, which temporarily alter perception, mood \u200band thinking. It is a pharmaceutical formulation of lysergide, better known as LSD, \u200band works by activating serotonin receptors in the brain.<\/div>\n<div>In April, U.S. President Donald Trump signed an executive order to speed up access to psychedelic-based treatments.<\/div>\n<div>Definium shares, which have gained about 174% \u200bso far this year, were trading up 52% at $37.23.<\/div>\n<div>Needham analyst Ami Fadia \u200bcalled the results &#8220;unprecedented in the depression space,&#8221; adding the drug showed greater reductions in scores \u200cat \u2060six weeks than Johnson &amp; Johnson&#8217;s (JNJ.N)<svg><\/svg><span>, opens new tab<\/span> Spravato and Compass Pathways&#8217; (CMPS.O)<svg><\/svg><span>, opens new tab<\/span> COMP360 achieved at week four.<\/div>\n<div>Axsome Therapeutics&#8217; (AXSM.O)<svg><\/svg><span>, opens new tab<\/span> Auvelity and Sage Therapeutics&#8217; Zurzuvae are some of the other treatments for major depressive disorder (MDD).<\/div>\n<div>&#8220;DT120 could emerge as a worthy competitor in the \u200bMDD \/ TRD space with \u200ba strong \u2060clinical profile,&#8221; Fadia added.<\/div>\n<div>Definium said the data brings it closer to an FDA submission and it was running a second \u200blate-stage depression trial.<\/div>\n<div>The drug was generally well-tolerated, with 99% \u200bof adverse \u2060events mild to moderate, occurring mainly on the day of dosing, and no serious safety issues or increase in suicidal thoughts observed.<\/div>\n<div>The trial enrolled 149 participants aged \u206018-74 \u200byears with MDD, the second-most common mental health \u200bdisorder in the U.S., with more than 21 million adults experiencing a major depressive episode each \u200byear.<\/div>\n<\/div>\n<p>Read more <a href=\"https:\/\/reliablemovingcrews.com\/?p=2709\">Uber board sued over alleged \u2018serial\u2019 compliance failures, sexual abuse lawsuits<\/a><\/p>\n<p>Read more <a href=\"https:\/\/reliablemovingcrews.com\/?p=2707\">Greenspan playbook to get a replay under Warsh<\/a><\/p>\n<p>Read more <a href=\"https:\/\/reliablemovingcrews.com\/?p=2705\">Trading Day: Mixed signals, Wall Street wobbles<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Definium Therapeutics said a single dose of its LSD-based experimental pill \u200bsignificantly reduced symptoms of major depression in patients in a late-stage \u200ctrial, sending its shares soaring 55% to a more than four-year high on Monday.<\/p>\n","protected":false},"author":1,"featured_media":2710,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[77,17,79,78],"class_list":["post-2711","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-health","tag-public-policy","tag-regulatory","tag-regulatory-oversight"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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